1. Feng L, Uteshev VV, Premkumar LS. Expression and Function of Transient
Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary
Tract. Int J Mol Sci. 2019 Apr 26;20(9). pii: E2065. doi: 10.3390/ijms20092065.
PubMed PMID: 31027359.
2. Sharma A, Ramena G, Yin Y, Premkumar L.S. Elble RC. CLCA2 is a positive
regulator of store-operated calcium entry and TMEM16A. PLoS One. 2018 May
14;13(5):e0196512. doi: 10.1371/journal.pone.0196512.
3. Pabbidi MR, Premkumar LS (2017) Role of Transient Receptor Potential Channels Trpv1 and Trpm8 in Diabetic Peripheral Neuropathy. J Diabetes Treat: JDBT-129.
4. Samineni VK, Premkumar LS, Faingold CL (2017). Neuropathic pain-induced enhancement of spontaneous and pain-evoked neuronal activity in the periaqueductal gray that is attenuated by gabapentin. Pain 158:1241-1253
PMID: 28328571.
5. Abooj M, Bishnoi M, Bosgraaf CA, Premkumar LS. (2017) Changes in spinal cord following inflammatory and neuropathic pain and the effectiveness of resiniferatoxin The Open Pain J. 8. 180-191.
6. Khare P, Jagtap S, Jain Y, Baboota RK, Mangal P, Boparai RK, Bhutani KK,
Sharma SS, Premkumar LS, Kondepudi KK, Chopra K, Bishnoi M. (2016) Cinnamaldehyde supplementation prevents fasting-induced hyperphagia, lipid accumulation, and inflammation in high-fat diet-fed mice. Biofactors. 42(2):201-11.
7. Yu S, Premkumar L.S. (2015) Ablation and regeneration of peripheral and Central TRPV1 Expressing Nerve Terminals and the Consequence of Nociception. The Open Pain J. 8, 1-9.
8. Baboota, R. K., Murtaza, N., Jagtap, S., Singh, D. P, Karmase, A., Kaur, J., Bhutani, K.K., Bopara,i R. K., Premkumar, L. S., Kondepudi, K. K., Bishnoi, M. (2014) Capsaicin-induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice. J Nutr Biochem. 25: 893-902.
9. Premkumar L. S. (2014) Transient Receptor Potential Channels as Targets for Phytochemicals. ACS Chem. Neurosci. 5: 1117-30.
10. Premkumar L. S, Pabbidi RM. Diabetic Peripheral Neuropathy: Role of Reactive Oxygen and Nitrogen Species. Cell Biochem Biophys. 67:373-83.
Premkumar L. S., Abooj M. TRP channels and analgesia. (2013) Life Sci. 92: 41524.
11. Cao, D.S., Zhong, L., Hsieh, T.H., Abooj, M., Bishnoi, M., Hughes, L., Premkumar. L.S.(2012) Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells. PLoS One 7(5):e38005. Epub 2012 May 31.
12. Evans, M.S., Cheng, X., Jeffry, J.A., Disney, K.E., Premkumar, L.S. (2012).
Sumatriptan inhibits TRPV1 channels in trigeminal neurons. Headache. May;52(5):773-84.
13. Bishnoi, M., Bosgraaf, C.A., Abooj, M., Zhong, L. and Premkumar, L.S. (2011) (2011)Streptozotocin-Induced Early Thermal Hyperalgesia is independent of Glycemic State of Rats: Role of Transient Receptor Potential Vanilloid 1(TRPV1) and Inflammatory mediators. Mol Pain 2011 Jul 27;7:52.
14. Raisinghani, M., Zhong, L., Jeffry, J.A., Bishnoi, M., Pabbidi, R.M., Pimentel, F., Cao, D.S., Evans, M.S. and Premkumar, L.S.(2011) Activation Characteristics of Transient Receptor Potential Ankyrin 1 and its Role in Nociception. Am J Physiol Cell Physiol. 301: C587-600.
15. Walia, V., Yu, Y., Cao, D., Sun, M., McLean, J.R., Hollier, B.G., Cheng, J., Mani, S.A., Rao, K., Premkumar, L. and Elble, R. C. (2011) Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis. Oncogene. 2011 Sep 12. doi: 10.1038/onc.2011.392. [Epub ahead of print]
16. Lee, R.H., Liu, Y.Q., Chen, P.Y., Liu, C.H., Chen, M.F., Lin, H.W., Kuo, J.S., Premkumar, L.S. and Lee, T.J. (2011) Sympathetic alpha 3 beta 2-nAChRs mediate cerebral neurogenic nitrergic vasodilation in the swine. Am J Physiol Heart Circ Physiol. 301: H344-354.
17. Samineni, V.K., Premkumar, L.S. and Faingold, C.L. (2011) Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray. Brain Res. 1389:177-82.
18. Bishnoi, M., Bosgraaf C. A. and Premkumar L. S.(2011a) Preservation of acute pain and efferent functions following intrathecal RTX-Induced analgesia J. Pain, 12: 991-1003 .
19. Premkumar, L. S. and Bishnoi, M. (2011) Disease-related changes in TRPV1 expression and its implications for drug development. Curr. Topics in Med. Chem.11: 2192-209.
20. Premkumar, L. S. and Pabbidi, R. (2011) Diabetic Peripheral Neuropathy: Role of reactive oxygen and nitrogen species Cell Biochem. Biophys. (in press).
21. Bishnoi, M. and Premkumar, L.S. (2011) Possible consequences of blocking TRPV1. Curr. Pharm. Biotechnol. 12: 102-114.
22. Liu G, Hu X, Premkumar L, Chakrabarty S. (2011) Nifedipine synergizes with calcium in activating the calcium sensing receptor, suppressing the expression of thymidylate synthase and survivin and promoting sensitivity to fluorouracil in human colon carcinoma cells. Mol Carcinog. 2011 Mar 3. doi: 10.1002/mc.20752. [Epub ahead of print]
23. Evans M.S., Cheng X., Jeffry J.A., Kimberly E. Disney K.E., Premkumar L. S. (2011) Sumatriptan inhibits TRPV1 channels in trigeminal neurons. Headache (in press).
24. Premkumar L, S. (2010) Targeting TRPV1 as an Alternative Approach to Narcotic Analgesics to Treat Chronic Pain Conditions. AAPS J. 12: 361-370.
25. Jeffry J. A., Yu S. Q., Sikand P., Parihar A., Evans M.S., and Premkumar L. S. (2009) Selective targeting of TRPV1 expressing central terminals of spinal cord for long lasting analgesia. PLoS One 15;4(9):e7021.
26. Walia V., Ding M., Kumar S., Nie D., Premkumar L. S., Elble R. C. (2009) hCLCA2 is a p53-inducible inhibitor of breast cancer cell proliferation. Cancer Res.69: 6624-6632.
27. Cao D. S., Yu S. Q., Premkumar L.S. (2009) Modulation of transient receptor potential vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C. Mol Pain 5(1):5.
28. Lin H. W., Liu C. Z., Cao D., Chen P.Y., Chen M. F., Lin S. Z., Mozayan M., Chen A. F., Premkumar L. S., Torry D.S and Lee T. J (2008). Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion.. Proc. Natl. Acad. Sci. U S A. 105:19526-1953.
29. Pabbidi R., Yu S-Q., Peng S., Khardori R., Pauza M. E and Premkumar L. S. (2008) Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity. Mol. Pain 4:9.
30. Premkumar L. S. and Sikand P. (2008) TRPV1: a target for next generation analgesics. Curr. Neuropharmacol. 6: 151-163 .
31. Pabbidi R., Cao D-S., Parihar A., Pauza M.E and Premkumar L. S. (2007) Direct Role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of TRPV1 in sensory neurons Mol. Pharmacol. 73: 995-1004.
32. Sikand P. and Premkumar L. S. (2007) Potentiation of glutamatergic synaptic transmission by protein kinase C mediated sensitization of TRPV1 at the first sensory synapse. J. Physiol. 581: 418-424.
33. Premkumar L. S. and Raisinghani M. (2006) Nociceptors in cardiovascular functions: complex interplay as a result of cyclooxygenase inhibition. Mol. Pain2:26.
34. Mozayan M., Chen M. F., Si M., Yi Chen P., Premkumar L. S., Lee T. J. (2006) Cholinesterase inhibitor blockade and its prevention by statins of sympathetic alpha7 nAChR-mediated cerebral nitrergic neurogenic vasodilation. J. Cereb Blood Flow Metab. 26: 1562-1576.
35. Premkumar L. S., Raisinghani M., Pingle S., Long C. and Pimentel, F. (2005) Downregulation of TRPM8 by protein kinase C mediated dephosphorylation. J. Neurosci.25: 11322-11329.
36. Premkumar L. S. (2005) Block of calcium activated potassium channels by cocaine J. Memb. Biol. 204: 129-36.
37. Van Buren J., Bhat S., Smith S., Pauza M., Premkumar L. S. (2005) Role of TRPV1 in diabetic peripheral neuropathy. Mol. Pain 1: 17.
38. Raisinghani, M., and Pabbidi, R., Premkumar L. S. (2005) Activation of TRPV1 by Resiniferatoxin: Implications in chronic pain conditions. J. Physiol. 567: 771-786.
39. Puntambekar P., Van Buren J., Raisinghani M., Premkumar L. S. and Ramkumar V. (2004) Direct interaction of Adenosine with the TRPV1 channel protein. J. Neurosci. 24: 3663-3671.
40. Raisinghani M. and Premkumar L. S. (2004). Block of Native and Cloned Vanilloid Receptor 1 (TRPV1) by Aminoglycoside Antibiotics. Pain 113: 123-133.
41. Premkumar L. S., Qi Z.H., Van Buren J. and Raisinghani M. (2004) Enhancement of potency and efficacy of NADA by PKC-mediated phosphorylation of vanilloid receptor. J. Neurophysiol. 91:1442-1449.
42. Watanabe J., Beck C., Kuner T., Premkumar L. S.and Wollmuth L. P. (2003) DRPEER: A motif in the extracellular vestibule conferring high Ca2+ flux rates in NMDA receptor channels. J. Neurosci. 22:10209-10216.
43. Ahern G. P. and Premkumar L. S.(2002). Voltage-dependent priming of vanilloid receptor: effects of agonists and phosphorylation state. J. Physiol. 545: 441-451.
44. Premkumar L. S., Agarwal S. and Steffen D. (2002). Single channel properties of native and cloned rat vanilloid receptors. J. Physiol. 545: 107-117.
45. Sasaki Y. F., Rothe T., Premkumar L. S., Das S., Cui J., Talantova M. V., Wong H. K., Gong X., Chan S. F., Zhang D., Nakanishi N., Sucher N. J. and Lipton S. A. (2002). Characterization and comparison of the NR3A Subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J. Neurophysiol. 87:2052-2063.
46. Chatterton J. E., Awobuluyi M., Premkumar L. S.,Takahashi H., Talantova M., Shin Y., Cui J., Tu S., Sevarino K. A., Nakanishi N., Tong G., Lipton S. A. and Zhang D. (2002). Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 415:793-798.
47. Premkumar L. S. (2001) Interaction between vanilloid receptors and purinergic metabotropic receptors: pain perception and beyond. Proc. Natl. Acad. Sci. U S A. 98:6537-6539.
48. Premkumar L. S. and Ahern G. P. (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990.
49. Kuehl-Kovarik C.M., Partin, M., Premkumar L. S. and Magnusson, K. R. (2000) Electrophysiological analysis of NMDA receptor subunit changes in the aging mouse cortex. Mech. Ageing Dev. 115:39-59.
50. Premkumar L. S. (1999) Selective potentiation of L-type calcium currents in cardiac myocytes and hippocampal neurons by cocaine. Mol. Pharmacol. 56:11381142.
51. Das D., Sasaki Y. F., Rothe T., Premkumar L. S., Takasu M., Crandall J. E., Dikkes P., Connor D. A., Rayudu P. V., Cheung W., Chen H-S.V., Lipton S. A. and Nakanishi N. (1998). Increased NMDA current and spine density in mice lacking a novel NMDAR subunit, NR3A. Nature393: 377-381.
52. Premkumar L. S. and Auerbach A. (1997) Stoichiometry of mouse recombinant NMDA receptor channels inferred from single-channel conductance patterns. J. Gen. Physiol. 110:485-502.
53. Premkumar L. S., Qin F. and Auerbach A. (1996) Subconductance states of a mutant NMDA receptor channel: kinetics and voltage-dependence. J. Gen. Physiol. 109: 1-9.
54. Premkumar L. S. and Auerbach A. (1996) Identification of a high affinity divalent binding site at the entrance of NMDA receptor channel. Neuron16: 869-880.
55. Sunstrom N.A., Premkumar L. S. Ewart G. Cox G. B. and Gage, P.W. (1996) Ion channel formed by NB, an influenza B virus protein. J. Membr. Biol. 150: 127-132.
56. Premkumar L. S. and Ahern G. P. (1995) Blockade of a resting potassium channel and modulation of synaptic transmission by ecstasy in the hippocampus. J. Pharmacol. Expt. Ther. 274: 718-722.
57. Premkumar L. S. and Chung S-H. (1995) Activation of K+channels by stimulation of metabotropic receptor stimulation. NeuroReport6: 765-768.
58. Premkumar L. S. and Gage P. W. (1994) Potassium channels activated by GABAB agonists and serotonin. J. Neurophysiol. 71: 2570-2575.
59. Kurmi J., Premkumar L. S., Birnir B. and Gage P. W. (1993) The influence of membrane potential on chloride channels activated by GABA in rat cultured hippocampal neurons. J. Membr. Biol. 136: 273-280.
60. Vasudevan S., Premkumar L. S., Stowe S., Gage P. W., Reilander H. and Chung S-H. (1992) Muscarinic acetylcholine receptor produced in recombinant baculovirus infected SF9 insect cells couples with endogenous G-proteins to activate ion channels. FEBS. Lett. 311: 7-11.
61. Premkumar L. S., Chung S-H. and Gage P. W. (1990) GABA-induced potassium channels in cultured neurons. Proc. R. Soc. Lond. B. 241: 153-158.
62. Premkumar L. S., Gage P. W. and Chung S-H. (1990) Coupled potassium channels induced by arachidonic acid in cultured neurons. Proc. R. Soc. Lond. B. 242: 17-22.
63. Chung S-H., Moore J. B., Xia L., Premkumar L. S. and Gage P. W. (1990) Characterization of single-channel currents using digital signal processing techniques based on hidden Markov models. Phil. Trans. R. Soc. Lond. Biol. 329: 265-285.
64. Almotrefi A. A., Dzimiri N., Aboul-Enein H. Y. and Premkumar L. S. (1993). Synthesis and pharmacological evaluation of the antifibrillatory effect of fluorinated derivatives of carazolol and celiprolol: comparison with propranolol. Gen. Pharmacol. 24: 721-725.
65. Almotrefi A. A., Aboul-Enein H. Y. and Premkumar L. S. (1989). Evaluation of antifibrillatory activity of fluorinated derivatives of indenolol and nadolol in isolated rabbit and rat hearts. Comparison with propranolol. Arch. Int. Pharmacodyn. Ther. 301: 122-130.